Nanocs provides a variety of chemically functionalized and bioconjugated hylauronic acid with different functionality. These functional Hylauronic acid products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
Specifications:
30~50 functional groups on each hylauronic acid molecule.
Hylauronci acid conjugates provided either in water solution and dried powder;
Nanocs provides a variety of chemically functionalized and bioconjugated chitosan polysaccharide with different functionality. These functional chitosan products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
Specifications:
10~50 functional groups on each chitosan molecule.
Chitosan conjugates provided either in water solution and dried powder;
Aldehyde functionalized dextrans (Dextran-CHO) are capable of reacting with amine or hydrazide groups via so called Schiff reaction. Nanocs provides a variety of chemically functionalized and bioconjugated dextran products with molecular weight ranged from 3,000 Da to 2,000 KDa. These functional dextrans were purified by size-exclusion chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
Dextrans are naturally synthesized polysaccharides with good water solubility, low toxicity and varied molecular weights. Dextrans modified with dyes and other biomolecules have been successfully used as long-term tracers for live cells. Nanocs also provides customerized dextran products for your special needs.
Specifications:
Form: Powder
Color: White to off-white
Functional groups: Aldehyde
Reactive to: Primary amine, hydrazide, hydroxyamine
Biotin functionalized polyethylene glycol (PEG-Biotin) is an avidin or streptavidin binding PEG derivative that is used to biotinylate biomolecules or other material surfaces. Biotin can be easily detected by biotin/streptavidin binding assay and is widely used for molecule target detection.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Desthiobiotin PEG amine (DSB-PEG-NH2) is one of Nanocs’ desthiobiotin PEG crosslinkers that have a reactive primary amine group on one PEG terminus and a desthiobiotin tag on the other PEG end. Desthiobiotin is a modified version of biotin. Compared to biotin, desthiobiotin binds to streptavidin, avidin and other biotin-binding proteins with lower affinity and it can be eluted from binding complex with much more gental conditions (i.e., by competitive displacement with regular, free biotin). As such, desthiobiotin reagent is a useful alternative to Biotin for avidin-biotin techniques in which nondenaturing elution of the labeled proteins is desired. Amine functionalized desthiobiotin can react with a number of amine reactive groups such as succinimidyl ester, carboxylic acid, aldehyde, etc. Reaction between amine and other groups allows quick and efficient conjugation of desthiobiotin tag to proteins, antibodies and other biomolecules. PEG linker between desthiobiotin and amine group offers better water solubility, reduced steric hindrance and enhanced reactivity.
Physical Properties:
Off-white/white solid;
Soluble in aqueous buffer, DMSO or DMF;
Reactive group: Primary amine (-NH2);
Reactive to: NHS, aldehyde, COOH, etc.;
Storage Conditions:
Store at <-20 0C. Desiccate. Avoid frequent thaw and freeze.
