Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-10k 10000 Da 100 mg修饰性聚乙二醇

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Pentafluorophenyl PEG, mPEG-PFP

Cat. No. PG1-PFP-10k Pentafluorophenyl PEG, mPEG-PFP           Cat. No. PG1-PFP-10k     10000 Da    100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

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Description:

Nanocs PFP (pentafluorophenyl) functionalized polyethylene glycol (PEG-PFP) is an amine (-NH2) reactive PEG derivative that can be used to modify molecules with available amine groups. Compared to NHS PEG, PFP PEG has greater reactivity, it can react with both prirmary and secondary amine groups at pH 7~9. Nanocs provides a number of PFP functionalized PEG derivatives that can be used for controlled amine pegylation applications.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Solubility: 10 mg/mL, clear in water, chloroform, DMSO.
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C, desiccate. PFP PEG tends to hydrolyze from moisture. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Methacrylate PEG, mPEG-MAR Cat. No. PG1-MAR-350 350 Da 1 g修饰性聚乙二醇

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Methacrylate PEG, mPEG-MAR

Cat. No. PG1-MAR-350 Methacrylate PEG, mPEG-MAR           Cat. No. PG1-MAR-350     350 Da    1 g
Specification 350 Da
Unit Size 1 g
Price $385.00

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Description:

Methacrylate functionalized polyethylene glycol (PEG methacrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-10k 10000 Da 100 mg修饰性聚乙二醇

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DSPE PEG Maleimide, DSPE-PEG-MAL

Cat. No. PG2-DSML-10k DSPE PEG Maleimide, DSPE-PEG-MAL           Cat. No. PG2-DSML-10k     10000 Da    100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

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Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

  • Form: Solid powder;
  • Color: White;
  • Solubility: Soluble in chloroform and warm water;
  • Reactive group: Maleimide;
  • Reactive to: Sulfhydryl (-SH);
  • Lipid type: 18C PE, saturated;
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-CADS-20k , DSPE PEG Acid, DSPE-PEG-COOH

Methoxy PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-1 5000 Da 1 g修饰性聚乙二醇

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Methoxy PEG Aldehyde, mPEG-CH2CHO

Cat. No. PG1-AL-5k-1 Methoxy PEG Aldehyde, mPEG-CH2CHO           Cat. No. PG1-AL-5k-1     5000 Da    1 g
Specification 5000 Da
Unit Size 1 g
Price $385.00

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PEG Aldehyde Description:

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 10- to 50-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 6~8.5.
  • PEG aldehyde stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-20k 20000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Pentafluorophenyl PEG, mPEG-PFP

Cat. No. PG1-PFP-20k Pentafluorophenyl PEG, mPEG-PFP           Cat. No. PG1-PFP-20k     20000 Da    100 mg
Specification 20000 Da
Unit Size 100 mg
Price $385.00

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Description:

Nanocs PFP (pentafluorophenyl) functionalized polyethylene glycol (PEG-PFP) is an amine (-NH2) reactive PEG derivative that can be used to modify molecules with available amine groups. Compared to NHS PEG, PFP PEG has greater reactivity, it can react with both prirmary and secondary amine groups at pH 7~9. Nanocs provides a number of PFP functionalized PEG derivatives that can be used for controlled amine pegylation applications.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Solubility: 10 mg/mL, clear in water, chloroform, DMSO.
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C, desiccate. PFP PEG tends to hydrolyze from moisture. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Lipoic acid PEG, mPEG-LA Cat. No. PG1-LA-5k 5000 Da 100 mg修饰性聚乙二醇

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Lipoic acid PEG, mPEG-LA

Cat. No. PG1-LA-5k Lipoic acid PEG, mPEG-LA           Cat. No. PG1-LA-5k     5000 Da    100 mg
Specification 5000 Da
Unit Size 100 mg
Price $325.00

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Description:

Lipoic acid, also known as thioctic acid, is an important bioactive molecule participating in various biological processes. PEG functionalized lipoic acid can be used to bind to metallic particle or film surface with its -S-S-bond. Lipoic acid group has high affinity to metallic surfaces and have been widely used for gold nanoparticles and quantum dots surfaces. PEGylated lipoic acid is water soluble and can be used directly in aqueous buffer.

Physical Properties:

  • Off-yellow solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Methacrylate PEG, mPEG-MAR Cat. No. PG1-MAR-350-5g 350 Da 5 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Methacrylate PEG, mPEG-MAR

Cat. No. PG1-MAR-350-5g Methacrylate PEG, mPEG-MAR           Cat. No. PG1-MAR-350-5g     350 Da    5 g
Specification 350 Da
Unit Size 5 g
Price $985.00

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Description:

Methacrylate functionalized polyethylene glycol (PEG methacrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-1k 1000 Da 100 mg修饰性聚乙二醇

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DSPE PEG Maleimide, DSPE-PEG-MAL

Cat. No. PG2-DSML-1k DSPE PEG Maleimide, DSPE-PEG-MAL           Cat. No. PG2-DSML-1k     1000 Da    100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

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Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

  • Form: Solid powder;
  • Color: White;
  • Solubility: Soluble in chloroform and warm water;
  • Reactive group: Maleimide;
  • Reactive to: Sulfhydryl (-SH);
  • Lipid type: 18C PE, saturated;
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-CADS-1k , DSPE PEG Acid, DSPE-PEG-COOH

DOPE PEG, mPEG-DOPE Cat. No. PG1-DO-5k 5000 Da 50 mg修饰性聚乙二醇

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DOPE PEG, mPEG-DOPE

Cat. No. PG1-DO-5k
Specification 5000 Da
Unit Size 50 mg
Price $485.00

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Description:

1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) conjugated Polyethylene Glycol, DOPE PEG is an unsaturated C18 phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Thiol PEG, mPEG-SH Cat. No. PG1-TH-5k-1 5000 Da 1 g修饰性聚乙二醇

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Thiol PEG, mPEG-SH

Cat. No. PG1-TH-5k-1 Thiol PEG, mPEG-SH           Cat. No. PG1-TH-5k-1     5000 Da    1 g
Specification 5000 Da
Unit Size 1 g
Price $325.00

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Synonym: PEG thiol, mPEG-SH, HS-PEG, Polyethylene glycol thiol, mPEG5000 Thiol, Thiol PEG5000

Description:

Thiol functionalized methoxyl polyethylene glycol, PEG thiol (mPEG-SH) is one of Nanocs monofunctional PEG derivatives that can be used to modify proteins, peptides and other materials. Thiol groups also have high affinity to gold surface and are widely used for gold nanoparticles or gold film modification. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Form: Solid
  • Color: White
  • Solubility: Soluble in water
  • Functional group: Thiol (-SH)
  • Purity: >95%
  • Applications: Surface modification, bioconjugation

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to see hundreds of publications using Nanocs PEGs

Documents
  • SDS
  • DataSheet

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PG1-TH-2k-1 , Thiol PEG, mPEG-SH
PG1-TH-2k-2 , Thiol PEG, mPEG-SH
PG1-TH-1k , Thiol PEG, mPEG-SH
PG1-TH-10k , Thiol PEG, mPEG-SH
PG1-TH-20k , Thiol PEG, mPEG-SH
PG1-TH-30k , Thiol PEG, mPEG-SH
PG1-TH-40k , Thiol PEG, mPEG-SH
PG1-TH-350 , Thiol PEG, mPEG-SH
PG1-TH-550 , Thiol PEG, mPEG-SH
PG1-TH-750 , Thiol PEG, mPEG-SH
PG1-TH-3k-1 , Thiol PEG, mPEG-SH
GP01-5-20 , Gold Nanoparticles, 5 nm, 0.01% Au

Azido PEG OPSS, N3-PEG-OPSS Cat. No. PG2-AZOS-3k 3400 Da 100 mg修饰性聚乙二醇

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Azido PEG OPSS, N3-PEG-OPSS

Cat. No. PG2-AZOS-3k
Specification 3400 Da
Unit Size 100 mg
Price $385.00

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Description:

Azide/azido functionalized polyethylene glycol (N3-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials. Azide group can react with alkyne in aqueous solution catalyzed by copper. It can also be reduced into amine group easily while another functional group can be react with other molecules or functional groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-2 5000 Da 5 g修饰性聚乙二醇

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PEG Aldehyde, mPEG-CH2CHO

Cat. No. PG1-AL-5k-2 PEG Aldehyde, mPEG-CH2CHO           Cat. No. PG1-AL-5k-2     5000 Da    5 g
Specification 5000 Da
Unit Size 5 g
Price $785.00

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PEG Aldehyde Description:

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 10- to 50-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 6~8.5.
  • PEG aldehyde stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Lipoic acid PEG, mPEG-LA Cat. No. PG1-LA-2k 2000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Lipoic acid PEG, mPEG-LA

Cat. No. PG1-LA-2k Lipoic acid PEG, mPEG-LA           Cat. No. PG1-LA-2k     2000 Da    100 mg
Specification 2000 Da
Unit Size 100 mg
Price $325.00

Qty Add to Cart

Description:

Lipoic acid, also known as thioctic acid, is an important bioactive molecule participating in various biological processes. PEG functionalized lipoic acid can be used to bind to metallic particle or film surface with its -S-S-bond. Lipoic acid group has high affinity to metallic surfaces and have been widely used for gold nanoparticles and quantum dots surfaces. PEGylated lipoic acid is water soluble and can be used directly in aqueous buffer.

Physical Properties:

  • Off-yellow solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Methacrylate PEG, mPEG-MAR Cat. No. PG1-MAR-350-10g 350 Da 10 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Methacrylate PEG, mPEG-MAR

Cat. No. PG1-MAR-350-10g Methacrylate PEG, mPEG-MAR           Cat. No. PG1-MAR-350-10g     350 Da    10 g
Specification 350 Da
Unit Size 10 g
Price $1,485.00

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Description:

Methacrylate functionalized polyethylene glycol (PEG methacrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-20k 20000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE PEG Maleimide, DSPE-PEG-MAL

Cat. No. PG2-DSML-20k DSPE PEG Maleimide, DSPE-PEG-MAL           Cat. No. PG2-DSML-20k     20000 Da    100 mg
Specification 20000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

  • Form: Solid powder;
  • Color: White;
  • Solubility: Soluble in chloroform and warm water;
  • Reactive group: Maleimide;
  • Reactive to: Sulfhydryl (-SH);
  • Lipid type: 18C PE, saturated;
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

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PG1-DS-20k , DSPE PEG, mPEG-DSPE
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PG2-DSML-20k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-DSPD-5k , DSPE-PEG-PDP

DOPE PEG, mPEG-DOPE Cat. No. PG1-DO-2k 2000 Da 50 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DOPE PEG, mPEG-DOPE

Cat. No. PG1-DO-2k
Specification 2000 Da
Unit Size 50 mg
Price $485.00

Qty Add to Cart

Description:

1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) conjugated Polyethylene Glycol, DOPE PEG is an unsaturated C18 phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Thiol PEG, mPEG-SH Cat. No. PG1-TH-5k-2 5000 Da 5 g修饰性聚乙二醇

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Thiol PEG, mPEG-SH

Cat. No. PG1-TH-5k-2 Thiol PEG, mPEG-SH           Cat. No. PG1-TH-5k-2     5000 Da    5 g
Specification 5000 Da
Unit Size 5 g
Price $885.00

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Description:

Thiol functionalized methoxyl polyethylene glycol, PEG thiol (mPEG-SH) is a monofunctional PEG derivative that can be used to modify proteins, peptides and other materials. Thiol groups also have high affinity to gold surface and are widely used for gold nanoparticles or gold film modification. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG1-TH-2k-2 , Thiol PEG, mPEG-SH
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PG1-TH-750 , Thiol PEG, mPEG-SH
PG1-TH-3k-1 , Thiol PEG, mPEG-SH

PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-2k 2000 Da 500 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Aldehyde, mPEG-CH2CHO

Cat. No. PG1-AL-2k PEG Aldehyde, mPEG-CH2CHO           Cat. No. PG1-AL-2k     2000 Da    500 mg
Specification 2000 Da
Unit Size 500 mg
Price $385.00

Qty Add to Cart

PEG Aldehyde Description:

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 10- to 50-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 6~8.5.
  • PEG aldehyde stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Pyrene PEG Cholesterol Cat. No. PG2-CSPN-2k 2000 Da 5 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Pyrene PEG Cholesterol

Cat. No. PG2-CSPN-2k
Specification 2000 Da
Unit Size 5 mg
Price $385.00

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nt pyrene derivatives that contain a cholesterol moiety on one PEG terminus. Cholesterol is an essentail lipid component to build and maintain basic animal cell functional. It is one of animal cell-mmbrane structure components and establishes proper membrane permeability and fluidity. In addition to its structural function, cholesterol is also the imporant precursor for the biosyntheis of steroid hormones, bile acids and viamin D. Pyrene is a unique fluorescent dye that has exceptionally long excite-state lifetimes (>100 nanoseconds). The long excited-state life time of this dye makes it useful for time-resolved fluorescent immonoassays, probing oxygen in cells and lipid vesicles. Pyrene labeled PEG cholesterol can be used to study cell membrane structures and other properties. PEG linker between Pyrene and Cholesterol offers better water solubility, less steric hindrance and enhanced stability. Compared to other common fluorescent dyes, Nanocs’ reactive fluorescent PEG dyes are brighter, more stable and easier to use. All our reactive fluorescent PEG dyes can be used directly in aqueous buffer without need adding any organic solvents.

Product Specifications:

  • Composition: Pyrene PEG Cholesterol;
  • Appearance: Colorless solid;
  • Solubility: Soluble in aqueous buffer;
  • Functional group: Cholesterol;
  • Reactive toward: Cell membrane, liposomes, etc.;
  • Excitation/Emission wavelength: 339 nm/384 nm.

Storage Conditions:

  • Store at -20 0C. Desiccate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Lipoic acid PEG, mPEG-LA Cat. No. PG1-LA-1k 1000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Lipoic acid PEG, mPEG-LA

Cat. No. PG1-LA-1k Lipoic acid PEG, mPEG-LA           Cat. No. PG1-LA-1k     1000 Da    100 mg
Specification 1000 Da
Unit Size 100 mg
Price $385.00

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Description:

Lipoic acid, also known as thioctic acid, is an important bioactive molecule participating in various biological processes. PEG functionalized lipoic acid can be used to bind to metallic particle or film surface with its -S-S-bond. Lipoic acid group has high affinity to metallic surfaces and have been widely used for gold nanoparticles and quantum dots surfaces. PEGylated lipoic acid is water soluble and can be used directly in aqueous buffer.

Physical Properties:

  • Off-yellow solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet