标签归档：拉帕

尼拉帕尼 Niraparib代理商

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上海金畔生物科技有限公司是尼拉帕尼 Niraparib代理商 ，欢迎访问官网了解更多产品信息和订购。
尼拉帕尼 Niraparib

详情介绍

Product Name: 尼拉帕尼 Niraparib

Description: Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.

Name: Niraparib free base
CAS#: 1038915-60-4 (free base)
Chemical Formula: C19H20N4O
Exact Mass: 320.1637
Molecular Weight: 320.4
Elemental Analysis: C, 71.23; H, 6.29; N, 17.49; O, 4.99

Synonym: MK-4827; MK 4827; MK4827; Niraparib. Niraparib free base; Zejula.

IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

InChi Key: PCHKPVIQAHNQLW-CQSZACIVSA-N

InChi Code: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N

Appearance: Light yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


拉帕替尼代理商

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上海金畔生物科技有限公司是拉帕替尼代理商 ，欢迎访问官网了解更多产品信息和订购。
拉帕替尼

详情介绍

Product Name: 拉帕替尼

Description: 拉帕替尼 is a synthetic, orally-active quinazoline with potential antineoplastic activity. 拉帕替尼 reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Check for active clinical trials or closed clinical trials using this agent.

Name: 拉帕替尼 (free base)
CAS#: 231277-92-2 (free base)
Chemical Formula: C29H26ClFN4O4S
Exact Mass: 580.13473
Molecular Weight: 581.06
Elemental Analysis: C, 59.94; H, 4.51; Cl, 6.10; F, 3.27; N, 9.64; O, 11.01; S, 5.52

Synonym: GSK572016; GSK-572016; GSK 572016; GW2016; GW-2016; GW 2016; 拉帕替尼. US brand name: Tykerb.

IUPAC/Chemical Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine

InChi Key: BCFGMOOMADDAQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

SMILES Code: O=S(CCNCC1=CC=C(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)O1)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001