加拿大Silicycle 金属清除剂

Silicycle 金属清除剂

近年来,快速合成出能够进入市场的药物的时间压力,使得使用金属催化剂的反应规模化增加,但反应后如何除去这些金属成为制药企业需要解决的关键问题。常规方法(色谱法,活性炭,蒸馏等)纯化原料药常常带来一些问题,如费用较高,时间较长,效率较低以及原料药损失。为了解决这个难题,加拿大SiliCycle公司推出SiliaMetS金属清除剂,它能够有效地解决原料药纯化过程遇到的金属离子超标的问题。

一、清除原理SiliaMetS

金属清除剂是功能化的硅胶,能够与多余的金属发生键合和反应。

二、SiliaMetS金属清除剂的特性和优点 

特性 优点
无污染物浸出 API不会被污染
高纯 每个SiliaMetS 产品的生产都遵循严格的质量控制流程,保证为客户提供无缺陷产品和100%满意度
高选择性 API回收率高
适用于多种金属态 大范围的金属催化剂都有效
反应速度快 室温下可以应用
省钱 清除剂用量少
溶剂用量少
溶剂兼容性 能够在任何溶剂中使用,水溶液pH 2-12
新技术兼容性 适用于微波合成和流体化学
优良的稳定性(热稳定和化学稳定) 可以在搅拌下使用
可以在高温条件下使用
易于使用和扩大 没有膨胀和静电
简单过滤即可去除
规模化从mg级到吨级
各种形式 SiliaSep固相萃取 SiliaPrep FLASH色谱柱
准确的负载量 保证批批重现
能提供大包装 能够提供多种包装,常备库存
二、选择依据 

可根据样品中含有的金属离子的种类进行选择实验优化条件:

三、条件优化

通过筛选过程,如果清除金属不完全,或您不满意清除效率或希望减少反应数量和反应时间,您将要进行如下的步骤:

1) 提高反应温度;

2) 调整SiliaMetS金属清除剂的量;

3) 改变反应时间;

4) 尝试不仅仅是一种,还有其它的SiliaMetS金属清除剂的使用。

这些因素可以只改变一种或者同时都改变来提高金属移除效率。特别要强调的是这些清除剂是在任何溶剂中使用均是稳定的。

产品名称 货号 清除离子 负载量mmol/g
SiliaMets Thiol R51030B Ag Hg Os Pd2+ Pd0Ru Cu Ir Pd Rh1+ Rh2+ Rh3+Sc Sn 1.2
SiliaMets Thiourea R69530B Ag Hg Os Pd2+ Pd0 Cu Fe Rh1+ Rh2+ Rh3+Sc Sn 1.2
SiliaMets Cysteine R80530B Cd Fe Ir Os Pd2+ Pd0Ru Sc Sn Ca Cr Cs Cu La Mg Pt Rh1+ Rh2+Zn 0.3
SiliaMets DMT R79030B Ir Ni Os Pd2+ Pd0 Pt Rh1+ Rh2+ Rh3+ Ru Co Cu Cd Fe Sc Zn 0.5
SiliaMets Amine R52030B Cd Cr Pt Rh1+ Rh2+Fe Pb Hg Ni Pd2+W Zn 1.2
SiliaMets Diamine R49030B Cr Pd2+ Pd0 Pt Cd Co Cu Fe Hg Ni Pb Ru W Zn 1.2
SiliaMets Triamine R48030B Cr Pd2+ Pd0 Pt Pb Co Cu Fe Ni  Ru 1.2
SiliaMets Imidazole R79230B Cd Fe Co Cu Ni Os W Zn Pd2+ Pd0 Cr Rh1+ Rh2+ 1.2
SiliaMets TAAcOH R69030B Co Ni Os Sc Fe Pd2+ Pd0 Cr Rh1+ Rh2+ Sn 0.4
SiliaMets TAAcONa R69230B Cd Fe Cs Cu Ni Ir La Li Mg Os Sc Sn Rh3+ Zn Pd2+Pd0 Cr Rh1+ Rh2+ 0.4

特级FBS,加拿大源,射线处理品牌代理商

上海金畔生物科技有限公司是特级FBS,加拿大源,射线处理品牌代理商 ,欢迎访问官网了解更多产品信息和订购。
特级FBS,加拿大源,射线处理

详情介绍

特级FBS,加拿大源,射线处理

产品名称:HyClone Characterized FBS, Canadian Origin, 500 mL, Irradiated 30-45kGy;特级FBS,加拿大源,射线处理

产品货号:SH30396.03IR30-45;

处理方式:3×100 nm滤膜过滤;

地区来源:加拿大;

物种来源:;

内毒素水平:内毒素水平:≤ 25 EU/mL;

血红素水平:< 25 mg/dL

热灭活:未灭活;

射线处理:处理;

保存条件:≤-10℃;

运输方式:干冰运输;

详细介绍:A cost-efficient alternative to defined FBS, this high-quality Canadian serum is well-characterized, triple 100 nm filtered, and virus-tested to 9 CFR standard.


Characterized: assayed for a variety of critical components and biochemical characteristics.

Canadian origin: sourced in Canada and processed in the US with complete traceability.

Endotoxin-tested: certificate of analysis confirms ≤ 25 EU/mL endotoxin.

Tripled-filtered: serial 100 nm pore size-rated filterings for reliable microbial depletion.

Post-filtration treatments: γ-irradiated and heat-inactivated FBS options also available.

Virus-tested: broad virus panel testing according toin accordance with 9 CFR 113.53.

Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that is high in growth factors and low in antibodies, compared to non-fetal sera.


Characterized FBS for cell culture

HyCloneTM Characterized Fetal Bovine Serum (FBS) is an excellent alternative to more expensive defined sera, and meets the requirements of most discriminating FBS users. The final serum is assayed for provides important proteins, hormones, growth factors, metabolites, and nutrients for that support your healthy cell culture sprocess. Assay results are included in the certificate of analysis and biochemical assay list. Additional testing, including EMEA conformance testing, is also available.


Bacterial endotoxin-tested

Endotoxin contamination is a significant concern in research and manufacturing, especially when producing cell culture-derived products for use in humans or animals. The presence of endotoxin in cell cultures can also have adverse and unpredictable effects on cell growth, function, and phenotype that can compromise research results. Our patented closed-system blood collection method and rigorous quality control testing ensure that HyClone Characterized FBS meets industry standards of ≤ 25 EU/mL endotoxin. The final product also contains ≤ 25 mg/dL hemoglobin, which is an indicator of appropriate handling during collection and transport.


Virus-tested and quality-assured for reduced contamination risk

HyClone Characterized FBS is triple-filtered through serial 100 nm (0.10 μm) pore size-rated filters, which has become an industry standard for cell culture grade FBS. Before dispensing, each lot of serum is pooled using true pool technology to minimize variability from bottle to bottle.


The final serum is virus-tested according to 9 CFR 113.53 to demonstrate that there are no detectable levels of specified viruses, pathogenic agents, and hemadsorbing agents. Robust sterility testing further confirms that the final product contains no detectable growth of bacteria or fungi (current USP) and no detectable mycoplasma.


Post-filtration treatments for added process security

Gamma-irradiated and heat-inactivated FBS options are available to further reduce the risk of adventitious agents, particularly when manufacturing products for use in humans or animals. The irradiation process is validated to deliver a minimum dose of 25 kGy.

特级加拿大进口FBS品牌代理商

上海金畔生物科技有限公司是特级加拿大进口FBS品牌代理商 ,欢迎访问官网了解更多产品信息和订购。
特级加拿大进口FBS

详情介绍

特级加拿大进口FBS

产品名称:HyClone Characterized FBS, Canadian Origin, 500 mL, Irradiated 25-40kGy, Heat-inactivated;特级加拿大进口FBS

产品货号:SH30396.03IH25-40;

处理方式:3×100 nm滤膜过滤;

地区来源:加拿大;

物种来源:;

内毒素水平:内毒素水平:≤ 25 EU/mL;

血红素水平:< 25 mg/dL

热灭活:灭活;

射线处理:处理;

保存条件:≤-10℃;

运输方式:干冰运输;

详细介绍:A cost-efficient alternative to defined FBS, this high-quality Canadian serum is well-characterized, triple 100 nm filtered, and virus-tested to 9 CFR standard.


Characterized: assayed for a variety of critical components and biochemical characteristics.

Canadian origin: sourced in Canada and processed in the US with complete traceability.

Endotoxin-tested: certificate of analysis confirms ≤ 25 EU/mL endotoxin.

Tripled-filtered: serial 100 nm pore size-rated filterings for reliable microbial depletion.

Post-filtration treatments: γ-irradiated and heat-inactivated FBS options also available.

Virus-tested: broad virus panel testing according toin accordance with 9 CFR 113.53.

Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that is high in growth factors and low in antibodies, compared to non-fetal sera.


Characterized FBS for cell culture

HyCloneTM Characterized Fetal Bovine Serum (FBS) is an excellent alternative to more expensive defined sera, and meets the requirements of most discriminating FBS users. The final serum is assayed for provides important proteins, hormones, growth factors, metabolites, and nutrients for that support your healthy cell culture sprocess. Assay results are included in the certificate of analysis and biochemical assay list. Additional testing, including EMEA conformance testing, is also available.


Bacterial endotoxin-tested

Endotoxin contamination is a significant concern in research and manufacturing, especially when producing cell culture-derived products for use in humans or animals. The presence of endotoxin in cell cultures can also have adverse and unpredictable effects on cell growth, function, and phenotype that can compromise research results. Our patented closed-system blood collection method and rigorous quality control testing ensure that HyClone Characterized FBS meets industry standards of ≤ 25 EU/mL endotoxin. The final product also contains ≤ 25 mg/dL hemoglobin, which is an indicator of appropriate handling during collection and transport.


Virus-tested and quality-assured for reduced contamination risk

HyClone Characterized FBS is triple-filtered through serial 100 nm (0.10 μm) pore size-rated filters, which has become an industry standard for cell culture grade FBS. Before dispensing, each lot of serum is pooled using true pool technology to minimize variability from bottle to bottle.


The final serum is virus-tested according to 9 CFR 113.53 to demonstrate that there are no detectable levels of specified viruses, pathogenic agents, and hemadsorbing agents. Robust sterility testing further confirms that the final product contains no detectable growth of bacteria or fungi (current USP) and no detectable mycoplasma.


Post-filtration treatments for added process security

Gamma-irradiated and heat-inactivated FBS options are available to further reduce the risk of adventitious agents, particularly when manufacturing products for use in humans or animals. The irradiation process is validated to deliver a minimum dose of 25 kGy.

HyClone特级胎牛血清(加拿大源)

上海金畔生物科技有限公司提供HyClone特级胎牛血清(加拿大源) ,欢迎访问官网了解更多产品信息和订购。
HyClone特级胎牛血清(加拿大源)

详情介绍

HyClone特级胎牛血清(加拿大源)

产品名称:HyClone Characterized FBS, Canadian Origin, 500 mL, Heat-inactivated;HyClone特级胎牛血清(加拿大源)

产品货号:SH30396.03HI;

处理方式:3×100 nm滤膜过滤;

地区来源:加拿大;

物种来源:;

内毒素水平:内毒素水平:≤ 25 EU/mL;

血红素水平:< 25 mg/dL

热灭活:灭活;

射线处理:未处理;

保存条件:≤-10℃;

运输方式:干冰运输;

详细介绍:A cost-efficient alternative to defined FBS, this high-quality Canadian serum is well-characterized, triple 100 nm filtered, and virus-tested to 9 CFR standard.


Characterized: assayed for a variety of critical components and biochemical characteristics.

Canadian origin: sourced in Canada and processed in the US with complete traceability.

Endotoxin-tested: certificate of analysis confirms ≤ 25 EU/mL endotoxin.

Tripled-filtered: serial 100 nm pore size-rated filterings for reliable microbial depletion.

Post-filtration treatments: γ-irradiated and heat-inactivated FBS options also available.

Virus-tested: broad virus panel testing according toin accordance with 9 CFR 113.53.

Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that is high in growth factors and low in antibodies, compared to non-fetal sera.


Characterized FBS for cell culture

HyCloneTM Characterized Fetal Bovine Serum (FBS) is an excellent alternative to more expensive defined sera, and meets the requirements of most discriminating FBS users. The final serum is assayed for provides important proteins, hormones, growth factors, metabolites, and nutrients for that support your healthy cell culture sprocess. Assay results are included in the certificate of analysis and biochemical assay list. Additional testing, including EMEA conformance testing, is also available.


Bacterial endotoxin-tested

Endotoxin contamination is a significant concern in research and manufacturing, especially when producing cell culture-derived products for use in humans or animals. The presence of endotoxin in cell cultures can also have adverse and unpredictable effects on cell growth, function, and phenotype that can compromise research results. Our patented closed-system blood collection method and rigorous quality control testing ensure that HyClone Characterized FBS meets industry standards of ≤ 25 EU/mL endotoxin. The final product also contains ≤ 25 mg/dL hemoglobin, which is an indicator of appropriate handling during collection and transport.


Virus-tested and quality-assured for reduced contamination risk

HyClone Characterized FBS is triple-filtered through serial 100 nm (0.10 μm) pore size-rated filters, which has become an industry standard for cell culture grade FBS. Before dispensing, each lot of serum is pooled using true pool technology to minimize variability from bottle to bottle.


The final serum is virus-tested according to 9 CFR 113.53 to demonstrate that there are no detectable levels of specified viruses, pathogenic agents, and hemadsorbing agents. Robust sterility testing further confirms that the final product contains no detectable growth of bacteria or fungi (current USP) and no detectable mycoplasma.


Post-filtration treatments for added process security

Gamma-irradiated and heat-inactivated FBS options are available to further reduce the risk of adventitious agents, particularly when manufacturing products for use in humans or animals. The irradiation process is validated to deliver a minimum dose of 25 kGy.

加拿大胎牛血清SH30396

上海金畔生物科技有限公司提供加拿大胎牛血清SH30396 ,欢迎访问官网了解更多产品信息和订购。
加拿大胎牛血清SH30396

详情介绍

加拿大胎牛血清SH30396

产品名称:HyClone Characterized FBS, Canadian Origin, 100 mL, Heat-inactivated;加拿大胎牛血清SH30396

产品货号:SH30396.02HI;

处理方式:3×100 nm滤膜过滤;

地区来源:加拿大;

物种来源:;

内毒素水平:内毒素水平:≤ 25 EU/mL;

血红素水平:< 25 mg/dL;

热灭活:灭活;

射线处理:未处理;

保存条件:≤-10℃;

运输方式:干冰运输;

详细介绍:A cost-efficient alternative to defined FBS, this high-quality Canadian serum is well-characterized, triple 100 nm filtered, and virus-tested to 9 CFR standard.


Characterized: assayed for a variety of critical components and biochemical characteristics.

Canadian origin: sourced in Canada and processed in the US with complete traceability.

Endotoxin-tested: certificate of analysis confirms ≤ 25 EU/mL endotoxin.

Tripled-filtered: serial 100 nm pore size-rated filterings for reliable microbial depletion.

Post-filtration treatments: γ-irradiated and heat-inactivated FBS options also available.

Virus-tested: broad virus panel testing according toin accordance with 9 CFR 113.53.

Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that is high in growth factors and low in antibodies, compared to non-fetal sera.


Characterized FBS for cell culture

HyCloneTM Characterized Fetal Bovine Serum (FBS) is an excellent alternative to more expensive defined sera, and meets the requirements of most discriminating FBS users. The final serum is assayed for provides important proteins, hormones, growth factors, metabolites, and nutrients for that support your healthy cell culture sprocess. Assay results are included in the certificate of analysis and biochemical assay list. Additional testing, including EMEA conformance testing, is also available.


Bacterial endotoxin-tested

Endotoxin contamination is a significant concern in research and manufacturing, especially when producing cell culture-derived products for use in humans or animals. The presence of endotoxin in cell cultures can also have adverse and unpredictable effects on cell growth, function, and phenotype that can compromise research results. Our patented closed-system blood collection method and rigorous quality control testing ensure that HyClone Characterized FBS meets industry standards of ≤ 25 EU/mL endotoxin. The final product also contains ≤ 25 mg/dL hemoglobin, which is an indicator of appropriate handling during collection and transport.


Virus-tested and quality-assured for reduced contamination risk

HyClone Characterized FBS is triple-filtered through serial 100 nm (0.10 μm) pore size-rated filters, which has become an industry standard for cell culture grade FBS. Before dispensing, each lot of serum is pooled using true pool technology to minimize variability from bottle to bottle.


The final serum is virus-tested according to 9 CFR 113.53 to demonstrate that there are no detectable levels of specified viruses, pathogenic agents, and hemadsorbing agents. Robust sterility testing further confirms that the final product contains no detectable growth of bacteria or fungi (current USP) and no detectable mycoplasma.


Post-filtration treatments for added process security

Gamma-irradiated and heat-inactivated FBS options are available to further reduce the risk of adventitious agents, particularly when manufacturing products for use in humans or animals. The irradiation process is validated to deliver a minimum dose of 25 kGy.

Hyclone加拿大特级胎牛血清

上海金畔生物科技有限公司提供Hyclone加拿大特级胎牛血清 ,欢迎访问官网了解更多产品信息和订购。
Hyclone加拿大特级胎牛血清

详情介绍

Hyclone加拿大特级胎牛血清

产品名称:HyClone Characterized FBS, Canadian Origin, 500 mL;Hyclone加拿大特级胎牛血清

产品货号:SH30396.03;

处理方式:3×100 nm滤膜过滤;

地区来源:加拿大;

物种来源:;

内毒素水平:内毒素水平:≤ 25 EU/mL;

血红素水平:< 25 mg/dL

热灭活:未灭活;

射线处理:未处理;

保存条件:≤-10℃;

运输方式:干冰运输;

详细介绍:A cost-efficient alternative to defined FBS, this high-quality Canadian serum is well-characterized, triple 100 nm filtered, and virus-tested to 9 CFR standard.


Characterized: assayed for a variety of critical components and biochemical characteristics.

Canadian origin: sourced in Canada and processed in the US with complete traceability.

Endotoxin-tested: certificate of analysis confirms ≤ 25 EU/mL endotoxin.

Tripled-filtered: serial 100 nm pore size-rated filterings for reliable microbial depletion.

Post-filtration treatments: γ-irradiated and heat-inactivated FBS options also available.

Virus-tested: broad virus panel testing according toin accordance with 9 CFR 113.53.

Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that is high in growth factors and low in antibodies, compared to non-fetal sera.


Characterized FBS for cell culture

HyCloneTM Characterized Fetal Bovine Serum (FBS) is an excellent alternative to more expensive defined sera, and meets the requirements of most discriminating FBS users. The final serum is assayed for provides important proteins, hormones, growth factors, metabolites, and nutrients for that support your healthy cell culture sprocess. Assay results are included in the certificate of analysis and biochemical assay list. Additional testing, including EMEA conformance testing, is also available.


Bacterial endotoxin-tested

Endotoxin contamination is a significant concern in research and manufacturing, especially when producing cell culture-derived products for use in humans or animals. The presence of endotoxin in cell cultures can also have adverse and unpredictable effects on cell growth, function, and phenotype that can compromise research results. Our patented closed-system blood collection method and rigorous quality control testing ensure that HyClone Characterized FBS meets industry standards of ≤ 25 EU/mL endotoxin. The final product also contains ≤ 25 mg/dL hemoglobin, which is an indicator of appropriate handling during collection and transport.


Virus-tested and quality-assured for reduced contamination risk

HyClone Characterized FBS is triple-filtered through serial 100 nm (0.10 μm) pore size-rated filters, which has become an industry standard for cell culture grade FBS. Before dispensing, each lot of serum is pooled using true pool technology to minimize variability from bottle to bottle.


The final serum is virus-tested according to 9 CFR 113.53 to demonstrate that there are no detectable levels of specified viruses, pathogenic agents, and hemadsorbing agents. Robust sterility testing further confirms that the final product contains no detectable growth of bacteria or fungi (current USP) and no detectable mycoplasma.


Post-filtration treatments for added process security

Gamma-irradiated and heat-inactivated FBS options are available to further reduce the risk of adventitious agents, particularly when manufacturing products for use in humans or animals. The irradiation process is validated to deliver a minimum dose of 25 kGy.