肽保护的惰性侧链氨基酸Fmoc-Val-Whaig resin树脂
上海金畔生物科技有限公司是我国较早生产离子交换树脂的厂家。有着多年的生产经验，我公司的产品生产工艺先进,质量可靠,广泛用于水处理,化工催化,冶金、提纯、制药,食品工业等。目前已和国内40多个省市的客户建立了业务关系，产品远销俄罗斯、美国、日本、韩国、印度等。
根据合成肽时侧链的活性，可把自然界中 20 种氨基酸分为惰性侧链氨基酸（如：Gly、Leu、Ile、Ala、Val 和 Phe 等）和活泼侧链氨基酸（如：侧链羧基、侧链氨基、侧链硫醇基和侧链杂环基等）。前一类只需保护 α-氨基，后一种氨基酸还需保护侧链活泼基团。由于主链保护基在接肽时脱去，侧链保护基在接肽后脱去，因此这两种保护基必需具有不同的脱去条件。
结构式：
【应用】
Fmoc-甘氨酸为Fmoc保护的甘氨酸，主要用于合成多肽，氨基酸保护基的不同对多肽合成的效率和产率有很大的影响。如Fmoc-甘氨酸可以用于制备一种甘氨酸衍生物缓蚀剂，通过酰胺化反应在甘氨酸分子上接入Fmoc-保护基团和疏水长链，通过杂原子（N、O等或不饱和键）和含π电子的双苯环吸附于金属，疏水长链阻挡水分 子，使其在钢铁表面形成一道保护膜，达到防腐的目的。
【合成】
甘氨酸是简单的氨基酸，在固相合成中，要把氨基保护起来才能接肽。用 Fmoc-Cl 于10％碳酸钠溶液和二氧六环条件下，低温与甘氨酸反应，可制得Fmoc-甘氨酸。实验过程中用薄层色谱监控反应进度，T.L.C 展开剂为：V(Et OH)：V(CHCl3)＝1：3，试验方程式如下：
Fmoc-甘氨酸合成具体步骤如下：
①3.0g 甘氨酸溶解于115ml 10％Na2CO3中，冷却到-4～0℃，11.2g Fmoc-Cl 溶解于 35.0ml 丙酮滴加到体系中，滴加完毕，冰浴搅拌30min，然后室温搅拌2.0h。
②用薄层色谱监控反应进度，反应完毕，倒入400ml水中，乙醚萃取两次，冷却并用浓盐酸调节 pH2 左右，析出大量白色固体，
③用50 ml乙酸乙酯萃取三次，无水硫酸镁干燥，减压蒸馏除去溶剂，用石油醚析出，得到 11.5g Fmoc-甘氨酸。提纯后，高效液相色谱测得产品纯度为97.3
产品目录：
Fmoc-Val-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Gly-Whaig resin 100-200 mesh, 1% DVB
Dilauryl thiodipropionate 100-200 mesh, 1% DVB
Amberlyst 15(H) ion-exchhaige resin 100-200 mesh, 1% DVB
Amberlite IR 120 100-200 mesh, 1% DVB
Na form, ion-exchhaige resin 100-200 mesh, 1% DVB
2-Chlorotrityl Chloride Resin 100-200 mesh, 1% DVB
Fmoc-Cys(Trt)-Whaig resin 100-200 mesh, 1% DVB
Polystyrene A-RAM 100-200 mesh, 1% DVB
Phenol-formaldehyde resin 100-200 mesh, 1% DVB
Merrifield resin 100-200 mesh, 1% DVB
Rink Amide MBHA 100-200 mesh, 1% DVB
Maleic haihydride-phthalic haihydride-diethylene glycol polymer
Rink Amide AM Resin 100-200 mesh, 1% DVB
Fmoc-Asp(OtBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Threoninol(tBu) DHP HM Resin 100-200 mesh, 1% DVB
DHP HM Resin 100-200 mesh, 1% DVB
H-Thr(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Phe(4-F)-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Asp-OAll-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Lys(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-D-Pro-Whaig resin 100-200 mesh, 1% DVB
H-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Asp-OAll-Whaig resin 100-200 mesh, 1% DVB
Fmoc-D-Pro-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Arg(Pbf)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-Trp-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Asp(OtBu)-Tcp Resin 100-200 mesh, 1% DVB
Fmoc-Lys(Dde)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-D-Tyr(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-Gln(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-Ser(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-D-Bip-Whaig Resin 100-200 mesh, 1% DVB
Dowex 1×8 200-400 exchhaige resin 100-200 mesh, 1% DVB
Whaig Resin 100-200 mesh, 1% DVB
Fmoc-Met-Whaig resin 100-200 mesh, 1% DVB
Fmoc-D-Ala-Whaig resin 100-200 mesh, 1% DVB
H-Asn-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-D-Phe-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Lys(Z)-Whaig resin 100-200 mesh, 1% DVB
Fmoc-D-Asn(Trt)-Whaig resin 100-200 mesh, 1% DVB
H-Lys(Boc)-Rink Amide AM Resin 100-200 mesh, 1% DVB
Fmoc-Ile-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Orn(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
H-Phe-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Arg(Pbf)-Tcp Resin 100-200 mesh, 1% DVB
Fmoc-Bpa-Whaig Resin 100-200 mesh, 1% DVB
Fmoc-Leu-Tcp Resin 100-200 mesh, 1% DVB
H-Glu-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-His(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Trp(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Lys(Ivdde)-Whaig resin 100-200 mesh, 1% DVB
H-Pro-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
"H-Asp(OtBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
货号：BD302494H-Asp(OtBu)-2-Chlorotrityl Resin 100-200 mesh, 1%"
Fmoc-D-Val-Whaig resin 100-200 mesh, 1% DVB
H-Tyr(tBu)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Leu-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Hydroxymethyl Resin 100-200 mesh, 1% DVB
H-Cys(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-N-Me-D-Phe-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-2-Nal-Whaig resin 100-200 mesh, 1% DVB
Rink Amide-AM Resin 100-200 mesh, 1% DVB
H-Tyr(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Trp(Boc)-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Asn(Trt)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Arg(Pbf)-Whaig resin 100-200 mesh, 1% DVB
H-Lys(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Thr-Whaig resin 100-200 mesh, 1% DVB
Weinreb AM Resin 100-200 mesh, 1% DVB
Fmoc-Pra-Whaig Resin 100-200 mesh, 1% DVB
H-Trp(Boc)-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-D-Gln(Trt)-Whaig resin 100-200 mesh, 1% DVB
Fmoc-Ser(tBu)-Rink Amide AM Resin 100-200 mesh, 1% DVB
H-β-Ala-2-Chlorotrityl Resin 100-200 mesh, 1% DVB
Fmoc-Pro-Whaig resin
Fmoc-Gly-Whaig resin
Fmoc-Arg(Pbf)-Whaig resin
Fmoc-Phe-Whaig resin
Fmoc-Trp(Boc)-Whaig resin
Fmoc-Asn(Trt)-Whaig resin
Fmoc-Leu-Whaig resin
Rink Amide-MBHA Resin
Fmoc-Tyr(Bzl)-Whaig Resin
Fmoc-Gln(Trt)-Whaig resin
Whaig resin
Fmoc-Ala-Whaig resin
Fmoc-D-Dab(Boc)-OH
Fmoc-Gly-Rink Amide AM Resin
H-Trp(Boc)-2-Chlorotrityl Resin
6-Chloro-L-Tryptophhai
2-Chlorotrityl Chloride Resin
Aminomethyl Polystyrene Resin
Sieber Amide Resin
Rink Amide-AM Resin
Trityl chloride
H-Ile-2-Chlorotrityl Resin
H-Gly-2-Chlorotrityl Resin
Fmoc-Ser(tBu)-Whaig resin
Fmoc-Asn(Trt)-OH
Boc-Tyr-OtBu
Fmoc-Hyp(tBu)-OH
Fmoc-Phe(2-F)-OH
Fmoc-Val-OH
Fmoc-D-Ala-NH2
Fmoc-N-Me-Ala-OH
Fmoc-D-Ala-Whaig resin
Fmoc-Pen(Acm)-OH
